Multi-drug resistance (MDR1) gene and P-glycoprotein influence on pharmacokinetic and pharmacodymanic of therapeutic drugs

(MDR1) gene expressed in tumor cells and also in several normal tissues, such as intestine, liver, kidney, blood-brain barrier, spinal cord, and placenta.P-gp has been identified in mice, rat, bovine, monkey, Clothing rodents, and human beings and has been receiving a particular clinical relevance because this protein expression limits brain access

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